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Year : 2019  |  Volume : 3  |  Issue : 1  |  Page : 1-5

A Prospective study of the effect of bromfenac on tear production

1 Department of Optometry, Faculty of Health Sciences, Abia State University, Uturu, Nigeria
2 Department of Statistics, Faculty of Physical Sciences, Abia State University, Uturu, Nigeria

Correspondence Address:
Dr. Bright Chiemezie Offorha
Department of Statistics, Faculty of Physical Sciences, Abia State University, Uturu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/MTSM.MTSM_24_19

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Context: The effect of bromfenac on tear production of 100 healthy participants aged 16–35 (mean age 23.65 ± 4.38 years) was studied using Schirmer's test. Aim: This study, therefore, is primarily geared toward finding out whether the observed positive effect of bromfenac on the management of dry eye is only as a result of its anti-inflammatory effect on the ocular surface. Settings and Design: The pretest, posttest method of experimental design was used and the posttest was at 30-min interval. The tear production was evaluated before and after the administration of 0.09% of bromfenac. Materials and Methods: Participants were first screened of any systemic or ocular problems. The tear production of the participants' right eye (OD) was measured before the topical administration of bromfenac. A drop of bromfenac was administered, and the tear production of the same OD was measured at 30, 60, and 90 min later and recorded. Statistical Analysis Used: Repeated measures analysis of covariance and t-test methods were used. Results: A decrease in mean tear production from the mean baseline value (19.76 ± 4.61 mm/5 min) was recorded after 30-min interval at 30 min, 60 min, and 90 min, respectively. The lowest mean tear produced was observed at 60 min, this effect was found to be statistically significant (P < 0.001). It was also found that gender significantly influence tear production after the administration of bromfenac. Conclusion: Tear production significantly declines with bromfenac administration almost equally in both genders. Patients prone to dry eyes should therefore use bromfenac cautiously regardless of gender.

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